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recombinant inbred strain
A recombinant inbred strain (or recombinant inbred line) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. F1 and F2 generations are produced by intercrossing the inbred strains; pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding.〔
Families of recombinant inbred strains numbering from 25 to 5000 are often used to map the locations of DNA sequence differences (quantitative trait loci) that contributed to differences in phenotype in model organisms. Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of organisms – ''Saccharomyces cerevisiae'' (yeast), ''Zea mays'' (maize), barley, ''Drosophila melanogaster'', ''C. elegans'' and rat.
==History==
The origins and history of recombinant inbred strains are described by Crow. While the potential utility of recombinant inbred strains in mapping analysis of complex polygenic traits was obvious from the outset, the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci). One of the initial motivations to use recombinant inbred strains is that expensive genotype data can be accumulated and reused – greatly simplifying mapping studies. Another factor is the precision of mapping that can be achieved using these strains compared to typical F2 intercross progeny.
As genotyping became progressively less expensive and more accurate the main advantage of using recombinant inbred strains and other genetic reference panels shifted to the ability to assemble massive and coherent databases on phenotypes (e.g., the GeneNetwork web service), and to use these coherent open-source data sets for large-scale collaborative research projects in predictive medicine and plant and animal research.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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